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Selective Pancreatic Beta Cell Activities by Ultra Dynamised Dilutions of Alloxan at Micro-doses: An Experimental Approach

Dr. Sunil Kumar

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The parallel studies with tolbutamide, glibenclamide and insulin conducted under identical laboratory conditions showed a sudden fall in blood sugar level which rose again on withdrawal of drug. Whereas, the dynamised dilutions of Alloxan stabilized the blood sugar level, B-cell counts and Growth hormone profile even after withdrawal of drug for 10-25 days in 65% of cases at microdoses of alloxan 30x <200x <1000x P:<0.01, <0.001 respectively.

The Histopathological studies of dynamised dilutions of 6x, 30x, 200x and 1000x potencies of alloxan exhibited mitosis in B-cells which in turn shows 50-60% of B-Cell counts along with perceptible decrease in blood sugar and an increase in growth hormone level. On the contrary, the documented report of drug induced B-cell regeneration was observed with Homoeopathic drug, Cephalandra indica Q in diabetised rats (Rastogi et al, 1998). Furthermore, Chakraborty et al 1980 and 1981 discerned the similar phenomenon of selective B-cell regenerative potentiality and protects the B-cells against necrotic effect with Pterocarpus marsupium roxb in diabetised rats.

Sulphonylurea compound produced hypoglycaemic condition in normal animals by stimulating the pancreatic beta cells to produce more insulin and by increasing the glycogen deposition in the liver. These drugs however, do not decrease blood glucose in alloxan-diabetic animals (Dulin, 1964). In contrast to the oral anti-diabetic agents, the exogenous administration of insulin is well known to produce hypoglycaemic in alloxan-diabetic subjects (Larner, 1975). It is therefore, conceivable that hypoglycaemic principles in the M. Charantia Q exert a direct effect in diabetic-rabbits probably by a mechanism similar to insulin (Kumar & Sundaran, 1998). Despite the fact that diabetic rabbits have virtually twice the food intake of a normal rabbit, most of the calories in this food are not available to support body weight gain.

The undynamised dilutions of test drug, vehicle, saline and dynamised vehicle did not show any hypoglycaemic potentiality on examination of histopathological parameters of certain cellular/neuronal components and biochemical estimations of blood sugar and growth hormone profile. These observations clearly indicate that the mechanical potentization decreases with the material quantity of the solute. While potentising, the energy supplied by the agitation/vigorous strokes, activates the solvent system/diluent medium to acquire and mimic the chemical specificity of original drug molecule and then act as therapeutic agent.

This implies two hypothesis, firstly the action of Homoeopathic potencies will alternate in two opposite directions either “Inhibitory” or “Stimulatory” in Biosystems depending upon whether the potency imitates the solutes of represents the replica of it. In view of this concept and Inhibitory action was noticed as a result of mechanical potentisation of dynamised dilutions of alcohol fed control which in turn brings about maximum toxicity and ultimately the animals were fatal in the corresponding groups.

Hence, the dynamised potentization process thus induced the diluent medium to acquire and then mimic the chemical specificity of alloxan. Sharma (1964) has also confirmed the anti-diabetic potentiality through controlled experiments of alloxan induced diabetes in rats with dynamised 30, 200 and 1000 potencies of alloxan. The present probe confirms the Homoeopathic principle of “Similia Similibus Curentur” in having the therapeutic potentiality as an anti-diabetic agent in dynamised dilutions of 30x, 200x, and 1000x of alloxan in diabetised rats and also demonstrates the phenomenon of minimum dose and its probable mechanism of action through hypothalamo-hypophysial-pancreatic axis.

Further probe in this area would be rewarding in order to achieve 100% stabilization of blood sugar level and restoration of Pancreatic B-cells.

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