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Selective Pancreatic Beta Cell Activities by Ultra Dynamised Dilutions of Alloxan at Micro-doses: An Experimental Approach

Dr. Sunil Kumar

The recent research conducted by Homoeopathic Drug Research Institute, Lucknow has confirmed the anti-diabetic potentiality of alloxan. It confirms the homoeopathic principle of ‘Similia similibus curentur’ in being an anti-diabetic agent in dynamised solutions.


Dynamised and undynamised preparations of Alloxan 6x, 30x, 200x, and 1000x were examined for its anti-diabetic activities in Alloxan-induced Diabetes mellitus albino rats. Oral administration of dynamised potencies of Alloxan 6x, 30x, 200x, and 1000x at a dose level of 50 u 1/100gm. b.w. daily for 30 days regularly exhibited slow and steady fall in blood sugar level accompanied with perceptible increased in Serum growth hormone (GH) i.e. p<0.01 (less significant) and p<0.001 (significant) respectively when compared to dynamised and undynamised control as well as undynamised Alloxan fed groups under identical conditions. Histological and histomorphometric studies also revealed regeneration of Pancreatic B-cells. Dynamised dilutions of Alloxan acts steadily through the hypothalamo-hypophysial pancreatic axis producing selective regeneration of B-cells at very micro dose and high dilutions 6x <30 <200x <1000x. the drug may indirectly release releasing factors from hypothalamic neurons, stimulating the secretion of growth hormone which in turn triggers optimum insulin secretion from B-cells. The therapeutic action of the test drug in dynamised dilutions at very micro dose and relatively high dilutions on pancreatic B-cell confirms the phenomenon of “Potentisation” & “Similia Similibus Curentur” and lack of acute and sub-acute toxicity may open up new prospects in the treatment of Diabetes mellitus and throw light in elucidating the mechanism of action at higher dilutions. It was noticed that the dynamised dilutions of alcohol fed control group is more toxic and lethal to animals than dynamised and undynamised dilutions of Alloxan and undynamised alcohol fed control groups. Furthermore, it was also discernible that blood sugar and growth hormone levels were stabilised even after withdrawal of dynamised test drug in its 30x, 200x and 1000x potencies.

Diabetes
Diabetes is not a disease but includes a variety of related disorders of metabolism, having common, an increase in blood sugar, usually accompanied by glycosuria. In many of these there is also a greater and lesser tendency to ketosis which is an important immediate danger and an increased liability to various forms of vascular degeneration i.e. a long-term risk.

The management of Diabetes mellitus by replacement therapy with Insulin and oral anti-diabetic drugs has revolutionised the concept of disease. However, the use of these drugs during the last three decades has exposed more intricate problems. The problems of insulin resistance, insulin insensitivity and insulin antibodies are intriguing. In view of these findings it has been conceivable that besides the existing anti-diabetic drugs, other modalities might offer more rational approach (Mukherjee et al 1979 a).

Homoeopathic medicines are prepared by successive reduction of (1:100) of the material quantities of the medicine (solute) in a solution with vigorous shaking/agitation at every stage. This procedure is termed as potentisation. The solvents normally used are water, ethyl alcohol (liquids), sucrose and lactose (solids). Beyond 12th potency (n) the presence of solute is 10-24 parts in 1 part of the solution. According to Avogadro’s hypothesis, there are 6.03x1023 molecules in a gram molecule of any substance. Hence, it is quite evident that physically there is no existence of solute in a solution, beyond this potency (high dilution). Despite this Homoeopathic potencies/preparations are therapeutically active even for n 1000. The centesimal potencies of 30,200 1M and above up to CM, MM are frequently employed in Homoeopathic practice.

The present experiment was designed with a view to locate the therapeutic efficacy of dynamised and undynamised dilutions of Alloxan, a chemical, its commercial name is 2,4,5,6 (1H, 3H) pyrimidinetetrone: 2;4,5,6 tetraoxihexahydropyridine, Mesoxalyurea of molecular formula C4H2N2O4 with molecular weight 160.09, purity 98.5%.

It is chiefly used in its ability to produce Diabetes mellitus in experimental animals.

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